Medulloblastoma-Pipeline Insight, 2021 | Analytical Research Cognizance

Medulloblastoma-Pipeline Insight, 2021

Published by ARCDI001
Report ID 1667938
Published date Mar 30, 2021
Category Pharmaceuticals and Healthcare
Total Pages 60
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DelveInsight’s, “Medulloblastoma - Pipeline Insight, 2021,” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Medulloblastoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
Global coverage
Medulloblastoma Understanding
Medulloblastoma: Overview
Medulloblastoma is a cancerous brain tumor that starts in the lower back part of the brain, called the cerebellum. Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur exclusively in the posterior fossa and have the potential for leptomeningeal spread. Signs and symptoms of medulloblastoma may include headaches, nausea, vomiting, tiredness, dizziness, double vision, poor coordination and unsteady walk. Medulloblastoma is diagnosed based upon thorough clinical and neurological evaluation, detection of characteristic symptoms and physical findings, patient history, and specialized diagnostic tests. Primary CNS tumors are graded based on the tumor location, tumor type, extent of tumor spread, genetic findings, the patient’s age, and tumor remaining after surgery, if surgery is possible. Treatment includes surgery, radiation therapy (in patients >3 years old), or chemotherapy. The most effective treatment for medulloblastoma is a combination of therapies.

"Medulloblastoma - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Medulloblastoma pipeline landscape is provided which includes the disease overview and Medulloblastoma treatment guidelines. The assessment part of the report embraces, in depth Medulloblastoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Medulloblastoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights
The companies and academics are working to assess challenges and seek opportunities that could influence Medulloblastoma R&D. The therapies under development are focused on novel approaches to treat/improve Medulloblastoma.

Medulloblastoma Emerging Drugs Chapters
This segment of the Medulloblastoma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Medulloblastoma Emerging Drugs
Silmitasertib (CX-4945): Senhwa Biosciences
Silmitasertib (CX-4945), an oral small molecule inhibitor of casein kinase 2 (CK2). It caused cell-cycle arrest and selectively induced apoptosis in cancer cells relative to normal cells. The drug is in Phase I/II clinical development for the treatment of Medulloblastoma. Silmitasertib is a first-in-class small molecule drug that targets Casein Kinase 2 (CK2), a protein involved in the DNA repair mechanism of cancer cells.

Omburtamab-Lu-177: Y-mAbs Therapeutics
Omburtamab-Lu-177 is a theranostic humanized monoclonal antibody 8H9, conjugated to 177 lutetium. The drug is in Phase I/II clinical development for the treatment of medulloblastoma. 177Lu-omburtamab-DTPA embodies the Company’s naked omburtamab antibody radiolabeled with lutetium-177, using DTPA to chelate the lutetium radioisotope to the antibody. Omburtamab antibody was developed by researchers at Memorial Sloan Kettering (“MSK”), which is exclusively licensed by MSK to Y-mAbs. As a result of this licensing arrangement, MSK has institutional financial interests in the compound and in Y-mAbs.
Further product details are provided in the report……..

Medulloblastoma: Therapeutic Assessment
This segment of the report provides insights about the different Medulloblastoma drugs segregated based on following parameters that define the scope of the report, such as:
Major Players in Medulloblastoma
There are approx. 12+ key companies which are developing the therapies for Medulloblastoma. The companies which have their Medulloblastoma drug candidates in the most advanced stage, i.e. Phase II include, Roche.

Phases
DelveInsight’s report covers around 12+ products under different phases of clinical development like
Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Route of Administration
Medulloblastoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Oral
Parenteral
Intravitreal
Subretinal
Topical

Molecule Type
Products have been categorized under various Molecule types such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy

Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Medulloblastoma: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Medulloblastoma therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Medulloblastoma drugs.

Medulloblastoma Report Insights
Medulloblastoma Pipeline Analysis
Therapeutic Assessment
Unmet Needs
Impact of Drugs

Medulloblastoma Report Assessment
Pipeline Product Profiles
Therapeutic Assessment
Pipeline Assessment
Inactive drugs assessment
Unmet Needs

Key Questions
Current Treatment Scenario and Emerging Therapies:
How many companies are developing Medulloblastoma drugs?
How many Medulloblastoma drugs are developed by each company?
How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Medulloblastoma?
What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Medulloblastoma therapeutics?
What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
What are the clinical studies going on for Medulloblastoma and their status?
What are the key designations that have been granted to the emerging drugs?

Key Players
Oncurious
Y-mAbs Therapeutics
Senhwa Biosciences
Sun Pharmaceutical Industries
Roche
Nelum
WPD Pharmaceuticals
Midatech
Kintara Therapeutics
VBI Vaccines
Oncoheroes Biosciences

Key Products
TB-403
Omburtamab-Lu-177
Silmitasertib
Sonidegib
Vismodegib
NLM 001
WP1066
Panobinostat
Dianhydrogalactitol
VBI 1901
2HIT medulloblastoma

Introduction
Executive Summary
Medulloblastoma: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Medulloblastoma – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Medulloblastoma companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Medulloblastoma Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Drug name: Company name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Vismodegib: Roche
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I/II)
Comparative Analysis
Omburtamab-Lu-177: Y-mAbs Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
Dianhydrogalactitol: Kintara Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Medulloblastoma Key Companies
Medulloblastoma Key Products
Medulloblastoma- Unmet Needs
Medulloblastoma- Market Drivers and Barriers
Medulloblastoma- Future Perspectives and Conclusion
Medulloblastoma Analyst Views
Medulloblastoma Key Companies
Appendix

Table 1 Total Products for Medulloblastoma
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
Figure 1 Total Products for Medulloblastoma
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products